Renoprotective Effect of Xanthine Oxidase Inhibitor, Topiroxostat
نویسندگان
چکیده
منابع مشابه
Renoprotective effect of the xanthine oxidoreductase inhibitor topiroxostat on adenine-induced renal injury.
The aim of the present study was to reveal the effect of a xanthine oxidoreductase (XOR) inhibitor, topiroxostat (Top), compared with another inhibitor, febuxostat (Feb), in an adenine-induced renal injury model. We used human liver-type fatty acid-binding protein (L-FABP) chromosomal transgenic mice, and urinary L-FABP, a biomarker of tubulointerstitial damage, was used to evaluate tubulointer...
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Topiroxostat is a novel inhibitor of xanthine oxidase, and is postulated to exert a renoprotective effect. Puromycin aminonucleoside nephrosis (PAN) is a rat model of minimal change nephrotic syndrome. In this study, we examined whether topiroxostat ameliorates the kidney injury in PAN rats that was induced by a single intraperitoneal injection of PA (100 mg/kg body weight). Rats were divided i...
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35 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) 36 from purine nucleotides. Numerous recent studies have revealed the prevalence of 37 metabolic syndrome including non-alcoholic fatty liver disease (NAFLD) or 38 steatohepatitis (NASH) to be related to hyperuricemia. However, it remains unclear 39 whether elevated serum UA during the development of NAFLD or NAS...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine Research
سال: 2019
ISSN: 1918-3003,1918-3011
DOI: 10.14740/jocmr3913